Advantages over extracting files or using special Live USB creation tools :
There is no persistence overlay for distributions which normally support it
My experience has been that the safest filesystem to use is FAT32 (surprisingly!), though it will mean that ISO images greater than 4GB won't be supported. Other filesystems supported by GRUB2 also work, such as ext3/ext4, NTFS and exFAT, but the boot of the distributions must also support it, which isn't the case for many with NTFS (Ubuntu does, Fedora doesn't) and exFAT (Ubuntu doesn't, Fedora does). So FAT32 stays the safe bet; make sure your device is partitioned with MBR (not GPT) for legacy BIOS and EFI hybrid support for peak compatibility.
Last modified 23 December 2025